At least 28 people have died while many others were injured when a train rammed into a steel barrier at Ramses station in central Cairo on Wednesday.
Footage circulating on social media showed fire with black smoke clouds billowing from the busy railway station.
Firefighters were deployed to the site trying to tackle the fire and to rescue as many people as possible.
Several victims were totally burned fleeing the blaze, while ambulances rushed to the scene to take the injured people to hospitals.
Egyptian state TV said the death toll is expected to rise further following the blaze.
Egypt’s National Railway Authority confirmed in a statement that the incident was not deliberate, saying that the high speed could have caused the train crash.
Shortly after the accident, Egypt’s Prime Minister accepted Transport Minister Hisham Arafat’s resignation.
Egypt has witnessed over the past few years a number of deadly rail accidents due to poor maintenance work.
Last March, two trains collided leaving at least 12 people killed, including a child.
In August 2017, 43 people were killed when two passenger trains collided in Alexandria.
In 2016, more than 50 people were killed when two commuter trains collided in Cairo.
Many have accused the government for failing to tackle the chronic transport problems in the country.