Foreign Office minister Baroness Saeeda Warsi has resigned from the government, saying she can “no longer support” its policy on Gaza.
She wrote on her Twitter feed that she was leaving with “deep regret”.
Lady Warsi, who was previously chairman of the Conservative Party, became the first female Muslim cabinet minister when David Cameron took office in 2010.
She grew up in Dewsbury, West Yorkshire, and worked as a solicitor before entering politics.
Lady Warsi was demoted from the cabinet to a middle-ranking Foreign Office post in 2012. She was made minister for faith and communities at the same time.
She wrote on Twitter on Tuesday: “With deep regret I have this morning written to the Prime Minister & tendered my resignation. I can no longer support Govt policy on #Gaza.”
Since the beginning of the war, Israel has killed 1,650 Palestinians, including 315 children, 166 women, and 58 elderly. It also wounded 8,900, including 2,307 children, 1,529 women and 287 elderly.
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According to official UN statistics, around 80 per cent of the fatalities of the Israeli bombing on Gaza have been civilians.